Coiled-coil interactions drive ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cells
Jason Tones, Jasper Jeffrey, Rachel M. Lackner, David M. Chenoweth, Huaiying Zhang
This study shows that overexpressed MAD1 forms phase-separated condensates that drive mitotic slippage by sequestering MAD2 and weakening the mitotic checkpoint.
iScience · Sep 24, 2025Peer-reviewedCell Biology