Huaiying Zhang

This study investigates the role of human PIF1 in ALT telomere maintenance, showing its involvement in DNA damage, G4 formation, and replication stress response, with implications for cancer therapy.

This study shows HSV-1 protein ICP4 increases nuclear fluidity to enable condensate formation, supporting viral replication.

This study shows that overexpressed MAD1 forms phase-separated condensates that drive mitotic slippage by sequestering MAD2 and weakening the mitotic checkpoint.

This study shows that high telomeric SUMO levels promote APB nucleation and enhance ALT efficiency through BLM recruitment and DNA synthesis.

This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.

The paper investigates how condensate material properties and chromatin heterogeneity influence nuclear condensate growth, revealing two physical mechanisms and a quantitative theory to explain these dynamics.

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.