David M. Chenoweth

Mechanism-Based Discovery of New TRIDs Targeting Ribosome Pockets

This paper identifies new TRIDs that target ribosome pockets to increase PTC readthrough, showing some are more potent than ataluren in vitro.

RNA-binding proteins activate transcription through defined molecular grammars

The paper identifies RNA-binding proteins (RBPs) that activate transcription through molecular grammars similar to transcription factors, revealing their role in transcriptional regulation and RNA processing.

Herpes simplex virus-1 fluidizes the nucleus enabling condensate formation

This study shows HSV-1 protein ICP4 increases nuclear fluidity to enable condensate formation, supporting viral replication.

Conditional Localization Pharmacology Manipulates Cell Cycle with Spatiotemporal Precision

This paper introduces a method to control kinase activity with spatiotemporal precision using conditional localization pharmacology, demonstrating its ability to manipulate the cell cycle.

Delivery of Peptide Coacervates to Form Stable Interaction Hubs In Cells

The paper develops peptide-based compartments that can be delivered into cells to sequester targets and degrade them, demonstrating potential for synthetic organelles in cell engineering.

Microtubule depolymerization at kinetochores restricts anaphase spindle elongation

The paper shows that microtubule depolymerization at kinetochores limits spindle elongation rather than moving chromosomes apart during anaphase.

Coiled-coil interactions drive ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cells

This study shows that overexpressed MAD1 forms phase-separated condensates that drive mitotic slippage by sequestering MAD2 and weakening the mitotic checkpoint.

Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency

This study shows that high telomeric SUMO levels promote APB nucleation and enhance ALT efficiency through BLM recruitment and DNA synthesis.

A toolbox for ablating excitatory and inhibitory synapses

The paper introduces three genetically encoded tools to specifically ablate excitatory and inhibitory synapses using E3 ligase-dependent degradation mechanisms.

Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

The paper investigates how condensate material properties and chromatin heterogeneity influence nuclear condensate growth, revealing two physical mechanisms and a quantitative theory to explain these dynamics.

Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractility-driven strain that inhibits fibril degradation

The paper examines how tissue stiffness scales with collagen levels across different tissues and finds sub-linear scaling that aligns with cellularized gels, suggesting contractility-driven strain inhibition of collagen degradation.

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.