CAMK2D causes heart failure in RBM20 cardiomyopathy
Maarten M.G. van den Hoogenhof, Javier Durán, Thiago Britto‐Borges, Elena Kemmling, Laura Konrad, David C. Lennermann, Joshua Hartmann, Laura Schraft, Julia Kornienko, Theresa Bock, Marcus Krüger, Christoph Dieterich, Lars Michael Steinmetz, Matthias Dewenter, Johannes Backs
This study identifies CAMK2D overactivation as the cause of heart failure in RBM20 cardiomyopathy and shows pharmacological inhibition can reverse cardiac dysfunction.
bioRxiv · May 23, 2025 · PreprintMolecular Biology