Christoph Dieterich

The paper maps m6A modifications and polyadenylation events in Plasmodium falciparum mRNAs, identifying stage-specific m6A sites and their potential role in 3' end processing.

The paper introduces an improved protocol and software for sequence-specific direct RNA sequencing of non-polyadenylated RNAs, validated on human rRNA and other RNA species.

QutRNA2 improves tRNA modification detection using Nanopore sequencing with GPU acceleration, achieving faster performance and identifying modifications in human and mouse tRNAs.

This study shows that eukaryotic tRNA ligases repair RNA breaks in ribosomes and other RNPs, restoring translational activity and maintaining transcriptome integrity.

This study identifies MLP as a non-canonical RNA-binding protein in cardiomyocytes and shows its RNA-dependent interaction with cytoskeletal complexes.

CAPRINI-M curates cardiac protein interactions using AI, integrating literature and structural data to improve PPI resource quality and performance.

The paper uses single molecule long-read sequencing to analyze transcriptomes in heart failure patients and controls, identifying novel isoforms and convergent isoform changes across different cardiomyopathy types.

ViREn is a two-step method that purifies dengue virus RNA with high purity, revealing a 5-methylcytosine modification mediated by NSUN6 that affects RNA turnover.

The paper shows that genomic G quadruplexes regulate mRNA splicing by recruiting RNA-binding proteins, with implications for cardiac function.

WarpDemuX-tRNA improves barcode multiplexing for nanopore tRNA sequencing with higher precision and efficiency.

The paper introduces MoDorado, an algorithm that detects tRNA modifications beyond those trained in existing models, identifying seven new modifications in S. pombe.

The paper uses large language models to extract molecular interaction networks from scientific texts, achieving high precision and recall in protein-protein and gene regulatory network relations.

This study identifies CAMK2D overactivation as the cause of heart failure in RBM20 cardiomyopathy and shows pharmacological inhibition can reverse cardiac dysfunction.

The paper identifies circRNAs that regulate excitatory synaptogenesis in rat hippocampal neurons by modulating miR-128-3p activity.

The paper introduces circtools 2.0, an enhanced software for circRNA detection and analysis, with new features for improved detection, probe design, conservation analysis, and support for Oxford Nanopore sequencing.

This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.

The paper introduces NMDtxDB, a database of human NMD target transcripts identified through a data-driven approach using transcriptome assembly and NMD activity comparisons.

The paper presents TACOMA, a web tool integrating transcriptomics and proteomics data from a TAC-induced heart failure model, revealing molecular mechanisms of cardiac remodelling and failure.

The paper develops a method to detect m6A modifications at single-molecular resolution using direct-RNA sequencing by creating synthetic data and a bespoke algorithm.

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

This study uses base editors and AAVMYO to correct Rbm20 mutations in cardiomyocytes, improving splicing and cardiac function in mouse models of dilated cardiomyopathy.

Magnetique provides an interactive web tool to explore transcriptome signatures of heart failure using RNA-seq data from cardiomyopathy patients and donors.

This study applies adaptive sampling to direct RNA sequencing, showing efficient depletion of mitochondrial transcripts in human and mouse samples.

The paper identifies circRAB3IP as a circRNA that modulates cell proliferation by altering gene expression and mRNA processing through interactions with SF3B1 in a paracrine manner.

The paper introduces JACUSA2, a software framework for analyzing RNA modification data from multiple sequencing platforms and experimental conditions, demonstrating its use on m6A detection datasets.

The paper investigates the role of RNPS1 in splicing regulation and NMD by analyzing transcriptome-wide effects of its knockdowns, finding that RNPS1 primarily regulates splicing through distinct domains and interacts with splicing factors.

This study shows that UPF3A and UPF3B redundantly activate nonsense-mediated mRNA decay in human cells, with their combined depletion inhibiting NMD and upregulating substrates.

This study identifies miR-138-5p as a regulator of short-term memory and inhibitory synaptic transmission in hippocampal interneurons, with implications for schizophrenia.

The paper shows that CAG repeat expansion in Huntington's disease disrupts splicing, reducing circular RNA production and affecting neural progenitors and striatum before symptoms appear.