p21(CIP1/WAF1)-mediated partial senescence supports steroidogenesis and therapy resistance in primary prostate cancer cultures
Emily Toscano, Valentina Maggio, Jose G. Alvarez-Meythaler, Javier Garcia, A. Celma, Jacques Planas, María Eugenia Semidey, Mercedes Marín‐Aguilera, Rosa Somoza, Begoña Mellado, Inés M. de Torres, Roser Ferrer, Juan Moróte, Rosanna Paciucci
This study identifies a CDKN1A-mediated partial senescence program in prostate cancer that supports steroidogenesis and therapy resistance.
bioRxiv · Jan 16, 2026 · PreprintCancer Biology