Lisa Willemsen

An Open Benchmark for Systems Vaccinology: Insights from the CMI-PB Challenges

The paper benchmarks computational models predicting B. pertussis booster vaccine responses using multi-omics data from three cohorts, identifying key predictors of immunity and establishing a community resource for systems vaccinology.

Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

This study compares immune responses to whole-cell and acellular pertussis vaccines, finding that Th1 polarization is maintained through an early interferon response in whole-cell vaccine recipients.

Putting computational models of immunity to the test - an invited challenge to predict B. pertussis vaccination outcomes

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

A systems vaccinology resource to develop and test computational models of immunity

The paper evaluates computational models predicting immune responses to Pertussis Booster vaccinations using a new community resource, finding that existing models perform poorly and new models show variable performance based on features and strategies.