Saonli Basu

The paper estimates heritability of subcortical brain volumes in adolescents using a multi-site cohort, finding high heritability in cerebellum cortex and hippocampus.

This study estimates the heritability of functional brain networks in adolescents using SNP and twin data from the ABCD study, finding low genetic contributions.

The paper analyzes how SNP heritability estimates are affected by admixture and directional LD, showing biases in random-effect estimators and implications for GWAS and polygenic prediction.

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

This study compares heritability estimators under different LD structures and relatedness, finding no significant performance differences between fixed and random SNP-effect methods.

The paper estimates SNP heritability in multi-ethnic data while accounting for population substructure using a modified method of moments approach.

This paper introduces PredLMM, a method for rapidly estimating SNP heritability in large cohorts by approximating linear mixed models using predictive process techniques.

The paper identifies a genetic variant in PROCR that influences protein C and factor VII levels, linking it to both reduced coronary artery disease risk and increased venous thromboembolism risk through opposing inflammatory and thrombotic mechanisms.

The paper analyzes de novo mutations in 1,465 genomes to show similar mutation rates across ancestries but reduced rates in the Amish population, with environmental factors possibly influencing mutation rates.