Differential contribution of direct and indirect pathways from dorsolateral and dorsomedial striatum to motor symptoms in Huntington's disease mice
Sara Conde-Berriozabal, Laia Sitjà‐Roqueta, Esther García-García, Lia García-Gilabert, Anna Sancho‐Balsells, Sara Fernández‐García, Ened Rodríguez-Urgellés, Albert Giralt, Javier López-Gil, Emma Muñoz‐Moreno, Anna Castañé, Guadalupe Sòria, Manuel José Rodríguez, Jordi Alberch, Mercè Masana
This study investigates how direct and indirect striatal pathways from DLS and DMS contribute to motor symptoms in HD mice, finding that these pathways are dysfunctional in HD.
bioRxiv · Jun 12, 2024 · PreprintNeuroscience