Mercè Masana

This study investigates how direct and indirect striatal pathways from DLS and DMS contribute to motor symptoms in HD mice, finding that these pathways are dysfunctional in HD.

This study investigates the role of the M2 cortex - superior colliculus circuit in Huntington's Disease, finding altered visual perception and behavioral responses in HD mice.

The paper shows that Egr1-dependent hippocampal neuronal ensembles limit motor learning in mice.

This study shows that RTP801 regulates synaptic transmission and motor learning by modulating synaptic plasticity in the motor cortex.

This study shows that optogenetic stimulation of fronto-striatal pathways in HD mice improves motor symptoms and synaptic plasticity.

This study shows that RTP801 mediates motor learning dysfunction in Huntington's disease by affecting synaptic plasticity, suggesting a therapeutic target through the RTP801/Akt/mTOR pathway.