Human melanoma cell lines that possess wild-type BRAF alleles but are dependent on ERBB4 and ERBB2
Vipasha Dwivedi, Lauren M. Lucas, R. H. Cooke, Jen Davis, Ella Wilson, Markelle Scott, Kaitlyn O’Daniel, Chloe Dion, Jaxon Kerley, Madison Zelan, Nicholas DeFeo, Victoria Huffman, Madison N. Ingrao, David J. Riese
This study investigates the role of ERBB4 heterodimers in driving the proliferation of BRAF-WT&RAS/NF1-mutant melanoma cell lines and shows that dominant-negative mutants of ERBB2 and EGFR inhibit clonogenic growth in some but not all cell lines.
bioRxiv · Aug 22, 2024 · PreprintCancer Biology