Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes
Maija Corey, Mahati Rayadurgam, Mousa Vatanmakanian, Alicia Gibbons, Carolina Altbaum, Jeamin Jung, Neha Reddy, Priyanka Saminathan, Kiyokazu Kakugawa, Sonia Sharma
This study shows DGUOK deficiency disrupts purine metabolism, leading to lipid accumulation and innate immune activation in hepatocytes, independent of mtDNA depletion.
The Journal of Immunology · Jul 15, 2026Peer-reviewedImmunology