Author

Jean-Laurent Casanova

University of Texas Southwestern Medical Center, Dallas;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aurelie Cobat· 2 shared Laurent AbeliD· 2 shared Abbas Solgi· 1 shared Abdollah Karimi· 1 shared Alexander Antipenko· 1 shared Alexandre BolzeiD· 1 shared Anne-Sophie LHonneur· 1 shared Aziz Belkadi· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Aurelie Cobat

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A novel patient with inherited TNF deficiency and tuberculosis

Narelle Keating, Mehrnaz Mesdaghi, Zahra Chavoshzadeh, Abdollah Karimi, Mohammad Saberi, Sinem Unal, Vincent Meynier, Camille Soudee, Candice Laine, Abbas Solgi, Samin Sharafian, Anne-Sophie LHonneur, Melanie Migaud, Yoann Seeleuthner, Aurelie Cobat, , Stephanie Boisson-Dupuis

The paper reports three patients with inherited TNF deficiency who developed tuberculosis, showing TNF's essential role in immunity against M. tuberculosis.

medRxiv · Nov 9, 2026 · PreprintGenetic & Genomic Medicine

Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants

Aziz Belkadi, Alexandre Bolze, Yuval Itan, Aurelie Cobat, Quentin B Vincent, Alexander Antipenko, Lei Shang, Bertrand Boisson, Jean-Laurent Casanova, Laurent Abel

This study compares whole-genome sequencing (WGS) and whole-exome sequencing (WES) in six individuals, finding WGS more effective at detecting coding variants, particularly SNVs, with fewer false positives.

Proceedings of the National Academy of Sciences · Apr 28, 2015Peer-reviewedGenetics