The paper reports three patients with inherited TNF deficiency who developed tuberculosis, showing TNF's essential role in immunity against M. tuberculosis.

medRxiv · Nov 9, 2026 · PreprintGenetic & Genomic Medicine

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín-Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, , Stéphanie Boisson‐Dupuis

Homozygosity for hypomorphic IL23R variants (G149R, G300V, R381Q) partly impairs IL-23-dependent IFN-γ production in patient cells; with L372F (effect inferred), they are enriched in tuberculosis, not MSMD or CMC patients.

The Journal of Experimental Medicine · Jul 9, 2026Peer-reviewedGenetics✦ In-depth digest

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Narelle Keating, Karen Doggett, Grace M. Bidgood, Lizeth G. Meza Guzman, Laura F. Dagley, Kunlun Li, Bailey E. Williams, Anna Gabrielyan, Carolina Alvarado, Benjamin J. Broomfield, Brigette C. Duckworth, Colin Hockings, Jumana M. Yousef, Evelyn Leong, Rhiannon Morris, , Sandra E. Nicholson

This study identifies ARAP2 as a regulator of IFN-gamma signaling by modulating SOCS1 function through a phosphorylation-dependent interaction.

Cell Reports · Dec 1, 2025Peer-reviewedCell Biology