Destabilization of the holo-DNA Polδ by loss of Pol32 confers conditional lethality that can be suppressed by stabilizing Pol31-Pol3 interaction
Kenji Shimada, Monika Tsai-Pflugfelder, Niloofar Davoodi Vijeh Motlagh, Neda Delgoshaie, Jeannette Fuchs, Susan M. Gasser
The paper identifies Pol31 mutations that suppress the lethality of Pol32 loss by stabilizing Pol3-Pol31 interaction, enhancing replication fork stability under stress.
bioRxiv · Feb 11, 2021 · PreprintMolecular Biology