HPL-2/HP1 and MET-2/SETDB1 bind distinct co-factors that promote heterochromatic foci, gene repression and organogenesis independently of H3K9 methylation
Colin E. Delaney, Lisa Fol, Jia Emil You…·Susan E. Mango
The paper shows HPL-2 and MET-2 function in parallel H3K9me-independent pathways for gene repression and organogenesis, using distinct co-factors.