Protection against maternal infection-associated fetal growth restriction - proof-of-concept with a microbial-derived immunomodulator OM85: safety and efficacy data
Naomi Scott, Jeff Lauzon-Joset, Anya Jones, Kyle Mincham, Niamh Troy, Jonatan Leffler, Michael Serralha, Susan Prescott, Sarah Robertson, Christian Pasquali, Anthony Bosco, Patrick Holt, Deborah Strickland
This study shows that OM85, an immunomodulator, reduces fetal loss and growth restriction in pregnant mice exposed to bacterial LPS or influenza, by modulating maternal inflammatory responses without impairing anti-microbial defenses.
Mucosal Immunology · May 1, 2017Peer-reviewedImmunology