Discovery of a novel stereospecific β-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis
Hua Wang, Alexander A. Fedorov, Elena V. Fedorov, Deborah M. Hunt, Angela Rodgers, Acely Garza-Garcia, Jeffrey B. Bonanno, Steven C. Almo, Luiz Pedro S. de Carvalho
This study identifies Rv2498c as a multi-functional β-hydroxyacyl-CoA lyase/thioesterase in Mtb involved in three metabolic pathways and shows its deletion attenuates Mtb in a mouse model.
bioRxiv · May 15, 2018 · PreprintBiochemistry