A Human Tumor Virus Recruits HSP70 Chaperone to Remodel Its Replisome on DNA
Li Wan, Xiaochen Li, Paul Vittot, Jeffrey Brodsky, Peter Wipf, Patrick S Moore, Yuan Chang
This study shows that MCV small T protein recruits HSP70 to facilitate LT helicase remodeling and DNA unwinding, revealing a conserved mechanism for replication complex assembly.
bioRxiv · Nov 9, 2026 · PreprintMolecular Biology