Author

Paul Vittot

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alexis CorneciD· 1 shared Amandine Maire· 1 shared Anny WangiD· 1 shared Aude G. BernheimiD· 1 shared Auguste Bouvier· 1 shared Axel BenchetritiD· 1 shared Benjamin R. MorehouseiD· 1 shared Catherine FaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alexis CornecORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Human Tumor Virus Recruits HSP70 Chaperone to Remodel Its Replisome on DNA

Li Wan, Xiaochen Li, Paul Vittot, Jeffrey Brodsky, Peter Wipf, Patrick S Moore, Yuan Chang

This study shows that MCV small T protein recruits HSP70 to facilitate LT helicase remodeling and DNA unwinding, revealing a conserved mechanism for replication complex assembly.

bioRxiv · Nov 9, 2026 · PreprintMolecular Biology

A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway

Delphine Bonhomme, Hugo Vaysset, Eirene Marie Q. Ednacot, Vasco Rodrigues, Yazan Salloum, Jean Cury, Anny Wang, Axel Benchetrit, Pierre Affaticati, Veronica Hernandez Trejo, Paul Vittot, Charlie Bories, Alexis Cornec, Jean‐Pierre Levraud, Pedro P. Hernández, , Enzo Z. Poirier

The paper identifies SIRanc, a human homolog of bacterial antiphage SIR2 proteins, and shows it mediates innate immunity via the TLR pathway by degrading NAD+.

Science · Jul 24, 2025Peer-reviewedImmunology

Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis

Raphaël Laurenceau, Paul Rochette, Elena Lopez-Rodriguez, Catherine Fan, Amandine Maire, Paul Vittot, Karol Melissa Cerdas-Mejías, Auguste Bouvier, Thea Chrysostomou, David Bikard

This paper introduces DGRec, a method using DGRs to enable targeted hyper-mutagenesis in E. coli, creating diverse variants that allow evasion of phage infection.

bioRxiv · Mar 24, 2025 · PreprintSynthetic Biology