Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation
Tyler M. McCullough, Vishakha Choudhary, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman, Janet Lynn Smith
This study investigates how polyketide synthase thioesterase domains direct substrate nucleophiles for macrolactone formation by analyzing structural and functional properties of modified TEs.
ACS Catalysis · Aug 6, 2024Peer-reviewedBiochemistry