Author
Harvard UniversityORCID 0000-0003-4615-6775Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
刘静涵, Meredith A. Skiba, Andrew Kruse
The paper reports structures of the AT1R coupled to G protein and ligands, revealing a microswitch network that determines G protein-biased signaling.
Kaitlin Rhee, Lawrence Shue, Akimasa Adachi…·Xin X. Zhou
This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.
Tyler M. McCullough, Vishakha Choudhary, David L. Akey…·Janet Lynn Smith
This study investigates how polyketide synthase thioesterase domains direct substrate nucleophiles for macrolactone formation by analyzing structural and functional properties of modified TEs.