Author

Janet Lynn Smith

University of MichiganORCID 0000-0002-0664-9228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:statistical model· 1

Frequent Co-Authors

David H. ShermaniD· 2 shared David L. AkeyiD· 1 shared Dheeraj Khare· 1 shared Estefanía Martínez ValdiviaiD· 1 shared Jacquelyn R. RobertsiD· 1 shared Jeffrey D. Kittendorf· 1 shared Jennifer J. Schmidt· 1 shared Lena G. GerwickiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

David H. ShermanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Redefining the Role of the EryM Acetyltransferase in Natural Product Biosynthetic Pathways

Yihua Li, Xunkun Liu, Natalia R. Harris, Jacquelyn R. Roberts, Estefanía Martínez Valdivia, Xinrui Ji, Janet Lynn Smith

The paper redefines EryM as an acetyltransferase, showing it lacks decarboxylation activity and reveals structural insights into GNAT enzyme function.

bioRxiv · Mar 7, 2025Biochemistry

Structure of a Putative Terminal Amidation Domain in Natural Product Biosynthesis

Michael R. Rankin, Dheeraj Khare, Lena G. Gerwick, David H. Sherman, William H. Gerwick, Janet Lynn Smith

The paper characterizes the structure of a putative terminal amidation domain in natural product biosynthesis and identifies its potential catalytic role.

Structure · Oct 28, 2024Peer-reviewedBiochemistry

Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation

Tyler M. McCullough, Vishakha Choudhary, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman, Janet Lynn Smith

This study investigates how polyketide synthase thioesterase domains direct substrate nucleophiles for macrolactone formation by analyzing structural and functional properties of modified TEs.

ACS Catalysis · Aug 6, 2024Peer-reviewedBiochemistry