Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens
Megan W. Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Kathleen P. Davis, Samuel Nitz, Juliane Weller, Thulasi Warrier, Diana K. Hunt, Yoelkys Morales, Tomohiko Kawate, Jeffrey L. Gaulin, Jon H. Come, Juan Hernandez-Bird, , Paul C. Blainey
This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.
Proceedings of the National Academy of Sciences · Mar 24, 2025Peer-reviewedMicrobiology