Deborah Tan Hung

The paper links CMV exposure-associated Type 1 immunity to improved long-term survival in sepsis without shock, but not in septic shock.

This study identifies kainate receptors' role in coordinating primitive hematopoiesis and hemogenic niche organization in zebrafish, showing their impact on hematopoietic stem cell development through endothelial Notch signaling.

This paper identifies a novel small-molecule inhibitor of Mycobacterium tuberculosis Pks13 through chemical-genetic interaction profiling and validates its mechanism of action.

The paper develops a CRISPRi system for studying essential genes in Pseudomonas aeruginosa, revealing gene function and small molecule interactions through phenotypic analysis.

This paper introduces a CRISPRi-based PROSPECT platform for drug discovery in M. abscessus, identifying new compound targets and revealing unexpected susceptibility to isoniazid.

The paper shows that Kmo produces 3-HK, which promotes macrophage lysosomal acidification via kainate receptor antagonism, enhancing resistance to Salmonella infection.

The paper analyzes 125 Pseudomonas aeruginosa isolates from clinical and environmental sources to assess genotype-phenotype correlations and niche specialization, finding that genomic diversity does not correlate with isolation source or most virulence traits, but Group B strains show higher cytotoxicity.

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

This paper introduces PerSpecTM, a method to predict antibiotic mechanisms of action by comparing transcriptional responses of new molecules to known perturbations, demonstrating its effectiveness with three new anti-Pseudomonas aeruginosa compounds.

This study uses deep learning to predict protein-protein interactions in bacterial pathogens, identifying new complexes involving essential genes and virulence factors, with half of tested predictions validated.

The paper synthesizes a 217 amino acid-long N-terminal domain of pyocin S2 using automated fast-flow peptide synthesis, achieving rapid production and selective uptake in Pseudomonas aeruginosa.

The paper develops a method to trace horizontal gene transfer and persistence of carbapenem resistance genes across bacterial species using genomic data from clinical isolates.

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

This study xenografts murine bone marrow cells into zebrafish embryos to study hematopoiesis and host-pathogen interactions, showing successful integration and immune response.