Cytoskeletal engineering through Formin-like 1 overexpression enhances T cell infiltration and antitumor potency in solid tumors
Jeffrey W. Chung, Jessica G. Olivas-Corral, Ashley M. Wood, Heidi Solis, Ashton L. Sigler, Edward Ning, Michelle E Allen, Kayla H Thompson, Jordan Jacobelli
This study shows that overexpressing FMNL1 in T cells improves their migration through tumor barriers, leading to better antitumor effects in solid tumors.
bioRxiv · Aug 25, 2026 · PreprintImmunology