24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells
Ci Zhu, Nicole Boucheron, Ramona Rîca, Valentina Stolz, Emina Halilbasic, Thierry Claudel, Osamah Al-Rubaye, Alexander Lercher, Maximilian Baumgartner, Lisa Sandner, Teresa Preglej, Marlis Alteneder, Veronika Mlitz, Claudia Daniela Fuchs, Daniela Hainberger, , Michael A Trauner
This paper shows that NorUDCA reduces TH17/Treg imbalance and intestinal inflammation by inhibiting glutaminolysis and mTORC1 signaling in TH17 cells.
bioRxiv · Feb 10, 2022 · PreprintMolecular Biology