Nicole Boucheron

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells

This paper shows that NorUDCA reduces TH17/Treg imbalance and intestinal inflammation by inhibiting glutaminolysis and mTORC1 signaling in TH17 cells.

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

This study shows that NorUDCA modulates CD8+ T cell metabolism and function, reducing hepatic inflammation in a mouse model of immune-mediated liver disease.