Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease
Yaroslav Markov, Ahana Priyanka, Leqi Xu, Weiwei Wang, Kyra Thrush, John T. González, Daniel S. Borrus, Jessica Kasamoto, Raghav Sehgal, Grace Zou, Jenel Fraij, Becky Catherine Carlyle, Steve Horvath, David Bennett, Hongyu Zhao, , Albert Higgins‐Chen
This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.
bioRxiv · Oct 16, 2025 · PreprintPathology