John T. González

This study evaluates epigenetic clocks for aging interventions, finding newer clocks trained on mortality or aging rates are more reliable than those based on chronological age.

This study evaluates the technical and biological reliability of 18 epigenetic clocks and shows that technical reliability does not predict biological reliability, which is critical for clinical applications.

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.

TranslAGE provides a standardized framework for benchmarking epigenetic aging biomarkers by harmonizing datasets and precomputing scores across multiple performance domains.

The paper identifies and characterizes age-invariant genes across multiple tissues in mice, finding they are stable across the lifespan and have distinct molecular features.

This study evaluates the responsiveness of DNA methylation aging biomarkers across 51 longevity interventions, identifying factors influencing their response and highlighting the utility of explainable clocks.

This paper develops a DNA methylation biomarker, DNAmSen, to measure cellular senescence and shows its correlation with age and age-related diseases.