Author

Jessica Kasamoto

Yale UniversityORCID 0000-0002-4604-6093Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Assay:DNA methylation· 3 Organism:human· 3 Approach:statistical model· 3 Approach:benchmark study· 2 Research Focus:differential expression· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Albert Higgins‐CheniD· 3 shared Daniel S. BorrusiD· 3 shared John T. GonzáleziD· 3 shared Raghav SehgaliD· 3 shared Grace ZouiD· 2 shared Judith ArmstrongiD· 2 shared Yaroslav MarkoviD· 2 shared Ahana PriyankaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenomics

Albert Higgins‐ChenORCID

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3 papers

Recent·Most cited

When to Trust Epigenetic Clocks: Avoiding False Positives in Aging Interventions.

Daniel S. Borrus, Raghav Sehgal, Judith Armstrong, Jessica Kasamoto, John T. González, Albert Higgins‐Chen

This study evaluates epigenetic clocks for aging interventions, finding newer clocks trained on mortality or aging rates are more reliable than those based on chronological age.

Aging Cell · Oct 1, 2026Peer-reviewedGenomics

Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease

Yaroslav Markov, Ahana Priyanka, Leqi Xu, Weiwei Wang, Kyra Thrush, John T. González, Daniel S. Borrus, Jessica Kasamoto, Raghav Sehgal, Grace Zou, Jenel Fraij, Becky Catherine Carlyle, Steve Horvath, David Bennett, Hongyu Zhao, , Albert Higgins‐Chen

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.

bioRxiv · Oct 16, 2025 · PreprintPathology

TranslAGE: A Comprehensive Platform for Systematic Validation of Epigenetic Aging Biomarkers

Daniel S. Borrus, Raghav Sehgal, Judith Armstrong, John T. González, Grace Zou, Jessica Kasamoto, Yaroslav Markov, Jessica Ann Lasky-Su, Albert Higgins‐Chen

TranslAGE provides a standardized framework for benchmarking epigenetic aging biomarkers by harmonizing datasets and precomputing scores across multiple performance domains.

bioRxiv · Oct 16, 2025 · PreprintGenomics