Quantitative determination of longitudinal CNS cholesterol loss during myelin damage and repair
Disni Dedunupitiya, Eden P. Go, Travis Witte, Ashlynn Elliott, Nishama De Silva Mohotti, Jenna M. Williams, Hiroko Kobayashi, Rashmi Binjawadagi, Heather Desaire, Meredith D. Hartley
This study quantifies longitudinal CNS cholesterol and ester levels in a mouse model during myelination, demyelination, and remyelination, revealing impaired cholesterol recovery after demyelination.
bioRxiv · Jun 9, 2026 · PreprintNeuroscience