Author

A. Denise R. Garcia

Drexel UniversityORCID 0000-0001-5809-3543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Ellen C. GingrichiD· 2 shared Andrew S Blaeser· 1 shared Anh Duc LeiD· 1 shared Ashley Carper· 1 shared Austin A. ColeyiD· 1 shared Corey C. HarwelliD· 1 shared Disni DedunupitiyaiD· 1 shared Elizabeth Zegarowicz· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersNeuroscience

Ellen C. GingrichORCID

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5 papers

Recent·Most cited

Temporal dynamics of CNS cholesterol esters correlate with demyelination and remyelination

Nishama De Silva Mohotti, Jenna M. Williams, Rashmi Binjawadagi, Hiroko Kobayashi, Disni Dedunupitiya, Jack M. Petersen, A. Denise R. Garcia, Meredith D. Hartley

This study shows that cholesterol ester levels rise during demyelination and decrease during remyelination in the brain but remain elevated in the spinal cord, suggesting a role for cholesterol esters in demyelinating diseases.

ACS Chemical Neuroscience · Dec 9, 2025Peer-reviewedNeuroscience

Astrocyte modulation of synaptic plasticity mediated by activity-dependent Sonic hedgehog signaling

Anh Duc Le, Marissa Fu, Ashley Carper, Elizabeth Zegarowicz, Riya Kumar, Gloria Zacharias, A. Denise R. Garcia

This study shows that neural activity activates Sonic hedgehog signaling in astrocytes, leading to synapse-modifying molecule expression and experience-dependent structural plasticity.

Journal of Neuroscience · Feb 3, 2025Peer-reviewedNeuroscience

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

Rachana Deven Somaiya, Katelyn Stebbins, Ellen C. Gingrich, Hehuang Xie, John N. Campbell, A. Denise R. Garcia, Michael A. Fox

The paper identifies SHH signaling from retinal ganglion cells to thalamic astrocytes as essential for GABAergic interneuron migration into the visual thalamus.

eLife · Oct 11, 2022Peer-reviewedNeuroscience

A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling

Ellen C. Gingrich, Kendra Case, A. Denise R. Garcia

This study identifies a subpopulation of astrocyte progenitors in the neonatal brain regulated by Sonic hedgehog signaling, contributing to cortical astrocyte development.

Neural Development · Jan 13, 2022Peer-reviewedNeuroscience

Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization

Steven Hill, Andrew S Blaeser, Austin A. Coley, Yajun Xie, Katherine A. Shepard, Corey C. Harwell, Wen‐Jun Gao, A. Denise R. Garcia

This study shows that Sonic hedgehog signaling in astrocytes is required for cell-type-specific synaptic organization and remodeling in the cortex.

eLife · Jun 13, 2019Peer-reviewedNeuroscience