Oncogenic PIK3CA mutations cause lineage-selective niche corruption
Oliwia N Mruk, Alexandra J. Musk, Sweta Swaminathan, А. А. Maslakova, Jenna N. Brydon, Ryan Corbyn, Jinyi Su, Beatrice Bottura, Sabrina J. Low, Robin L. Pflughaupt, Leo M. Carlin, Robert K. Semple, Ralitsa Radostinova Madsen
This study shows that PIK3CA mutations cause lineage-specific niche changes in vascular endothelium, leading to tissue malformations that can be partially prevented by PI3K inhibition.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology