Author

Ryan Corbyn

Cancer Research UKORCID 0000-0002-6488-0495Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Leo M. CarliniD· 2 shared AJ Chalmers· 1 shared Alexandra J. MuskiD· 1 shared Beatrice BotturaiD· 1 shared Crispin J. MilleriD· 1 shared Jenna N. Brydon· 1 shared Jinyi SuiD· 1 shared JL BirchiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Leo M. CarlinORCID

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2 papers

Recent·Most cited

Oncogenic PIK3CA mutations cause lineage-selective niche corruption

Oliwia N Mruk, Alexandra J. Musk, Sweta Swaminathan, А. А. Maslakova, Jenna N. Brydon, Ryan Corbyn, Jinyi Su, Beatrice Bottura, Sabrina J. Low, Robin L. Pflughaupt, Leo M. Carlin, Robert K. Semple, Ralitsa Radostinova Madsen

This study shows that PIK3CA mutations cause lineage-specific niche changes in vascular endothelium, leading to tissue malformations that can be partially prevented by PI3K inhibition.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Radiotherapy drives lung metastasis in PDAC via a RhoGTPasesignaling shift towards MRCK-dependency

Kathy McLay, Mathias Tesson, Louise R. Dutton, Yihong Sun, Josette M Misquitta, Katrina H. Stevenson, Ryan Corbyn, Sérgio Lilla, Lynn McGarry, N Maka, R Shaw, Crispin J. Miller, LM Carlin, AJ Chalmers, Michael F. Olson, , JL Birch

This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.

bioRxiv · Sep 9, 2025 · PreprintCancer Biology