Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine
Izabella Sall, Randi L. Foxall, Lindsey C. Felth, Soren Maret, Zachary Rosa, Anirudh Gaur, Jennifer Calawa, Nadia Pavlik, Jennifer Lynne Whistler, Cheryl A. Whistler
The paper identifies microbiota-driven butyrate production as a factor maintaining antinociception in mice resistant to morphine tolerance.
Gut Microbes · Jan 12, 2025Peer-reviewedSystems Biology