Lindsey C. Felth

Dynamic flexibility of the gut microbiota to morphine disturbance enables escape from the stable dysbiosis associated with addiction-like behavior

The paper examines how gut microbiota changes in mice with addiction-like behavior, finding that compulsive morphine use leads to stable dysbiosis while non-compulsive mice show more flexible microbial adaptation.

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

The paper identifies microbiota-driven butyrate production as a factor maintaining antinociception in mice resistant to morphine tolerance.