Anirudh Gaur

The paper examines how gut microbiota changes in mice with addiction-like behavior, finding that compulsive morphine use leads to stable dysbiosis while non-compulsive mice show more flexible microbial adaptation.

The paper identifies microbiota-driven butyrate production as a factor maintaining antinociception in mice resistant to morphine tolerance.

This study shows that GASP1-mediated GLP-1R trafficking contributes to tolerance to incretin drugs, suggesting a strategy to prevent tolerance by biasing drug engagement toward G protein signaling.