Nuclear Pct1 couples phosphatidylcholine synthesis with membrane biogenesis
Pawel K Lysyganicz, Zenon Toprakcioglu, Jennifer Guo, António Daniel Barbosa, Benjamin Jenkins, Koini Lim, Albert Koulman, Tuomas P. J. Knowles, Marcus K. Dymond, David B. Savage, Symeon Siniossoglou
The paper shows that Pct1, a nuclear enzyme in yeast, senses lipid imbalance and coordinates phosphatidylcholine synthesis with membrane biogenesis.
bioRxiv · Apr 23, 2026 · PreprintCell Biology