David B. Savage

The paper shows that Pct1, a nuclear enzyme in yeast, senses lipid imbalance and coordinates phosphatidylcholine synthesis with membrane biogenesis.

The paper identifies novel proteins that relocalize in adipocytes in response to insulin, highlighting their role in insulin signaling.

This study evaluates 'kill or cure' strategies for MFN2-related lipodystrophy, finding that ethanol mildly worsens the condition in mice while rapamycin is well-tolerated but lacks efficacy in targeting Mfn2R707W cells.

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

This study uses population-scale whole genome sequencing to identify novel rare protein-coding variants associated with cardiometabolic traits, revealing new biological mechanisms and gene functions.

This study conducts a GWAS on a UK lipoedema cohort, identifying genetic loci associated with the disease, including those related to lipoma formation and hormone biosynthesis.

The paper identifies molecular and metabolic signatures of cardiometabolic syndrome using extreme phenotype groups and shows changes after bariatric surgery.

This study identifies rare loss of function variants in four genes associated with beneficial changes in body fat distribution using genome-wide and exome-sequence data from UK Biobank.

This study identifies rare variant associations with fat distribution and cardio-metabolic risk, implicating intracellular lipolysis genes in these traits.