Albert Koulman

The paper uses patient-derived iPSC-dopamine neurons to screen compounds and identifies the FASN-SREBP1 axis as a potential therapeutic target for Parkinson's disease.

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

This study identifies CLN8 as a stereospecific GPG acyltransferase critical for BMP biosynthesis, showing its loss causes Batten disease and that S,S-LPG supplementation can restore BMP and improve neurological symptoms.

The paper shows that Pct1, a nuclear enzyme in yeast, senses lipid imbalance and coordinates phosphatidylcholine synthesis with membrane biogenesis.

The paper introduces a new computational module, Functional Lipid Analysis (FLA), to assess lipid function through 42 indices, linking lipidomic data to biological pathways and enabling systems-level insights.

This study identifies ZFP57 as a regulator of postnatal growth and lifelong health by influencing mammary gland function and lactation, with effects on offspring metabolic syndrome.

This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.

The paper identifies common and syndrome-specific omics responses to acute illness in children and shows how malnutrition modifies host responses.

This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.

This study shows that infant gut microbiota at 1 month are most responsive to dietary changes, while 18-month-olds show resilience, with formula affecting fewer metabolic pathways than breast milk.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper identifies molecular and metabolic signatures of cardiometabolic syndrome using extreme phenotype groups and shows changes after bariatric surgery.

This study shows maternal diet-induced obesity alters fetal cardiac lipidomes and serum lipidomes differently in male and female fetuses, with female hearts showing greater sensitivity.

The paper identifies genetic associations between blood lipid metabolites and cardiometabolic disease loci in South Asian populations using lipidomics data from two studies.

The paper uses a novel computational tool to analyze lipid metabolism changes in offspring due to paternal diet, identifying tissue-specific lipid alterations linked to cardio-metabolic disease risk.

This study identifies genetic associations with metabolite levels across multiple cohorts and links these variants to clinical outcomes like type 2 diabetes and macular telangiectasia type 2.

The paper shows that parental exposure to P. vranovensis increases offspring survival through upregulation of CYSL-1, CYSL-2, and RHY-1.