Development of a preclinical screening platform for clinically relevant therapy of Dravet syndrome
Jeffrey A. Mensah, Kyle E. Thomson, Jennifer Huff, Tia S Freeman, Christopher A. Reilly, Joseph E. Rower, Cameron S. Metcalf, Karen S. Wilcox
This study evaluates the efficacy of stiripentol add-on to clobazam and valproic acid in a Scn1aA1783V/WT mouse model of Dravet syndrome, showing reduced seizure frequency and therapeutic plasma concentrations.
Epilepsia · Jun 30, 2025Peer-reviewedPharmacology & Toxicology