Christopher A. Reilly

Development of a preclinical screening platform for clinically relevant therapy of Dravet syndrome

This study evaluates the efficacy of stiripentol add-on to clobazam and valproic acid in a Scn1aA1783V/WT mouse model of Dravet syndrome, showing reduced seizure frequency and therapeutic plasma concentrations.

Validation studies and multi-omics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior

The paper validates Zhx2 as a quantitative trait gene influencing brain oxymorphone levels and opioid behavior through genetic and multi-omics analyses in mice.

Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach

The paper evaluates the pharmacokinetics of antiseizure drugs in rodent models to assess their efficacy and duration of action.

The tunicate metabolite 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine targets ion channels of vertebrate sensory neurons

This study identifies DIMTA, a marine tunicate metabolite, as a selective inhibitor of cold thermosensors in mice, increasing cold sensation threshold by >3°C.

Nicotinic acetylcholine receptor partial antagonist polyamides from tunicates and their predatory sea slugs

The paper identifies molleamine C as a partial antagonist of nicotinic acetylcholine receptors with potential for neuroactive drug development.