De novo Rubisco design with protein language models
Alexander J. Kehl, Simon K. S. Chu, Jose Henrique Pereira, Jennifer Lee, Renée Z. Wang, Michael Gigl, Paul D. Adams, Patrick M. Shih, Justin B. Siegel
This paper designs novel Rubisco variants using protein language models, identifying active candidates with improved CO2/O2 specificity and structural validity.
bioRxiv · Sep 9, 2026 · PreprintBiochemistry