Author

Alexander J. Kehl

Lawrence Berkeley National LaboratoryORCID 0000-0002-0993-5828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:large language model· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Jennifer Lee· 2 shared Jose Henrique PereiraiD· 2 shared Justin B. SiegeliD· 2 shared Patrick M. ShihiD· 2 shared Paul D. AdamsiD· 2 shared Alexander L. JaffeiD· 1 shared Caroline Yeow· 1 shared Jillian F. BanfieldiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Jennifer Lee

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2 papers

Recent·Most cited

De novo Rubisco design with protein language models

Alexander J. Kehl, Simon K. S. Chu, Jose Henrique Pereira, Jennifer Lee, Renée Z. Wang, Michael Gigl, Paul D. Adams, Patrick M. Shih, Justin B. Siegel

This paper designs novel Rubisco variants using protein language models, identifying active candidates with improved CO2/O2 specificity and structural validity.

bioRxiv · Sep 9, 2026 · PreprintBiochemistry

Diversity-driven biochemical survey reveals dimeric structural origin of rubisco

Alexander J. Kehl, Leah J. Taylor‐Kearney, Alexander L. Jaffe, Jose Henrique Pereira, Jennifer Lee, Michal Hammel, Lucas M. Waldburger, Caroline Yeow, Luis E. Valentin-Alvarado, Paul D. Adams, Jillian F. Banfield, Justin B. Siegel, Noam Prywes, Patrick M. Shih

The paper characterizes the structural and functional diversity of rubisco by synthesizing and analyzing diverse sequences, revealing a dimeric origin and a novel large rubisco structure.

bioRxiv · Nov 5, 2025 · PreprintBiochemistry