40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay
Akruti Shah, Aaztli R. Coria, Jennifer Miller, Emilien Orgebin, Wilfried M. Guiblet, Acong Yang, Shuo Gu, Colin Chih‐Chien Wu
RIOK3 displaces eS26 from ubiquitinated 40S subunits, exposing the 18S rRNA 3' end for U-tailing by TUT4/TUT7 and exonucleolytic decay by DIS3L2, which commits defective subunits to turnover.
bioRxiv · Sep 12, 2026 · PreprintMolecular Biology✦ In-depth digest