Author

Akruti Shah

National Cancer InstituteORCID 0000-0001-9557-4952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:long-read sequencing· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaztli R. CoriaiD· 2 shared Colin Chih‐Chien WuiD· 2 shared Emilien OrgebiniD· 2 shared Wilfried M. GuibletiD· 2 shared Acong YangiD· 1 shared Indra Mani SharmaiD· 1 shared Jennifer Miller· 1 shared Jennifer T. Miller· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Aaztli R. CoriaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 12, 2026

✦ In-depth digest

40S Ribosome Remodeling Triggers 18S rRNA U-tailing and DIS3L2-dependent Decay

Akruti Shah, Aaztli R. Coria, Jennifer Miller…·Colin Chih‐Chien Wu

RIOK3 displaces eS26 from ubiquitinated 40S subunits, exposing the 18S rRNA 3' end for U-tailing by TUT4/TUT7 and exonucleolytic decay by DIS3L2, which commits defective subunits to turnover.

1 citation

humanlong-read sequencing

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Molecular BiologyMolecular CellPeer-reviewedFeb 1, 2025

The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

Aaztli R. Coria, Akruti Shah, Mohammad Shafieinouri…·Colin Chih‐Chien Wu

This study identifies the integrated stress response (ISR) as a regulator of 18S nonfunctional rRNA decay in mammals through GCN2 and RNF10-mediated ubiquitination of ribosomal proteins.

38 citationstop 1%

humanstatistical model

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