Acong Yang

RIOK3 displaces eS26 from ubiquitinated 40S subunits, exposing the 18S rRNA 3' end for U-tailing by TUT4/TUT7 and exonucleolytic decay by DIS3L2, which commits defective subunits to turnover.

This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.

The paper identifies a POLR3B variant causing mis-splicing and altered Pol III transcriptome, revealing La protein's role in reshaping small ncRNA profiles and identifying tRF-1/tRF-3 as biomarkers for POLR3 deficiency.

The paper investigates how TENT2, TUT4, and TUT7 regulate miRNA 3' tailing, showing specific effects on sequence and abundance.

The paper shows that flexible pri-miRNA structures enable the production of 5' isomiRs through alternative Drosha cleavage, influenced by RNA-binding proteins in cancer.

The paper shows that structural differences in pri-miRNA paralogs lead to alternative Drosha cleavage, generating miRNAs with expanded target repertoires and distinct roles in tumor progression.