Colin Chih‐Chien Wu

RIOK3 displaces eS26 from ubiquitinated 40S subunits, exposing the 18S rRNA 3' end for U-tailing by TUT4/TUT7 and exonucleolytic decay by DIS3L2, which commits defective subunits to turnover.

This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.

This study identifies the integrated stress response (ISR) as a regulator of 18S nonfunctional rRNA decay in mammals through GCN2 and RNF10-mediated ubiquitination of ribosomal proteins.

This study identifies eEF3's role in promoting tRNA dissociation from the E site during translation elongation in fungi, revealing structural insights into the yeast translation cycle.

The paper identifies Cue2 as the endonuclease responsible for cleaving mRNAs at stalled ribosomes during No Go Decay and shows it acts as a secondary decay pathway.