Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes
Terri Pietka, Edward F. Morris, Megan Basco, Jennifer Shew, Ni-Huiping Son, Zhenxiu Liu, Brandon S.J. Davies, Ira J. Goldberg, Clair Crewe, Nada A. Abumrad
This study identifies nSMase2-generated exosomes as a mechanism for adipocyte LPL secretion and transfer to endothelial cells via GPIHBP1.
bioRxiv · Jul 31, 2025 · PreprintCell Biology